Findings of High B-Value Q-Space Imaging of the Brain in Children with Neurofibromatosis 1

A relatively new imaging technique, q-space imaging (QSI), uses multiple b-values to generate displacement profiles of diffusing molecules. Unidentified bright objects observed in children affected by neurofibromatosis have been reported to display increased apparent diffusion coefficient values compared to normal-appearing brain regions. To our knowledge this is first report of the findings of high-b-value QSI, including quantification of mean displacement, in these lesions and normal-appearing brain in 2 cases of neurofibromatosis.